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ChemInform Abstract: Combinatorial Synthesis of 2-Thioxo-4-dihydropyrimidinones.

✍ Scribed by M. M. SIM; C. L. LEE; A. GANESAN

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Combinatorial Synthesis of 2-Thioxo-4-dihydropyrimidinones.

-Pharmaceutically interesting title compounds are available following the synthetic sequence shown in the scheme. Aminomethylated polystyrene [cf. conditions C)] is a convenient agent to remove excess aldehyde and isothiocyanate and avoids an aqueous work-up. A library with 125 products is prepared from 5 aldehydes, 5 isothiocyanates (both types readily available with high diversity) and 5Ξ²-amino acid methyl esters (available by homologation of the Ξ±-amino acids). -(SIM, M.

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