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ChemInform Abstract: ′Click′ Assembly of Selective Inhibitors for MAO-A.

✍ Scribed by Zhao Jia; Qing Zhu

Publisher: John Wiley and Sons
Year: 2011
Weight: 24 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201109137

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✦ Synopsis

A 108 compounds library of 1,4-disubstituted triazoles is efficiently constructed using click chemistry. The fingerprint of the inhibitory activity toward monoamine oxidases against this library is obtained, and four hit compounds (III) are identified. Especially compound (IIIa) exhibits excellent inhibitory activity and selectivity toward MAO-A. -(JIA, Z.; ZHU*, Q.;

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