ChemInform Abstract: C(I)-Substituted Menthol Derivatives: Self-Removing Chiral Auxiliaries for Asymmetric Conjugate Additions to Cycloalkenones.

C(1)-Substituted menthol derivatives: Se

C(1)-Substituted menthol derivatives: Self-removing chiral auxiliaries for asymmetric conjugate additions to cycloalkenones

✍ Raymond L. Funk; Ge Yang 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 137 KB

C(l)-substituted (-)-menthone derivatives 3 were prepared by the stereoselective addition of the alkenyllithium reagents 9 to menthone (8) and subsequent acid catalyzed hydrolysis of the dioxolane protecting groups. Conjugate addition of cuprate reagents to enones 3a,b followed by a methanol quench