ChemInform Abstract: Chlorination of Nucleosides by N-Chlorodiisopropylamine and Triphenylphosphine.
โ Scribed by Yi-Sui Zhou; Z.-W. Miao; Yu-Fen Zhao
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Unprecedented Chlorination of 2,2'-Anhydro-5,6-dihydropyrimidine Nucleosides During DDQ Oxidation. -Nucleosides (Ia)-(Ib) undergo an unexpected ring opening and chlorination at C-2' position in the presence of DDQ to give dihydrothymidine derivatives (III). The sulfonyl ester (Ic) does not provide
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