ChemInform Abstract: Chiral Synthons from Carvone. Part 35. Carvone Based Approaches to Chiral Functionalized B-seco-Taxanes.

✍ Scribed by A. SRIKRISHNA; T. J. REDDY; P. P. KUMAR

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199911200

✦ Synopsis

Chiral Synthons from Carvone. Part 35. Carvone Based Approaches to Chiral Functionalized B-seco-Taxanes. -Starting from carvone (I) the synthesis of the B-seco-taxane derivative (VIII) is achieved. This method is extended incorporating an oxygen functionality in the taxane skeleton. Phenylacetylene (IX) is used as a 1,2-dioxygenated ethyl group equivalent. Beside the synthesis of C-aromatic bis-nortaxane derivatives, a C-20 nortaxane derivative is synthesized employing an appropriate aliphatic C-ring precursor. -(SRIKRISHNA, A.; REDDY, T.