✦ LIBER ✦
ChemInform Abstract: Chiral Indane Skeleton Based Thiourea Catalyzed Highly Stereoselective Cascade Michael—Enolization—Cyclization Reaction.
✍ Scribed by Qiao Ren; Yaojun Gao; Jian Wang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 30 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
The cascade Michael addition—enolization—cyclization reaction of β,γ‐unsaturated α‐ketoesters (I) and (IV) with cyclohexanedione (II) is smoothly catalyzed by a novel bifunctional tertiary amine—thiourea organocatalyst to give highly functionalized hexahydrobenzopyranones (III) and (V), resp., in high enantioselectivity.