ChemInform Abstract: Chiral Auxiliary-Bearing Isocyanides as Synthons: Synthesis of Strongly Fluorescent (+)-5-(3,4-Dimethoxyphenyl)-4-((N-((4S)-2-oxo-4-( phenylmethyl)-2-oxazolidinyl)) carbonyl)oxazole and Its Enantiomer.

✍ Scribed by J. S. TANG; J. G. VERKADE

• Book ID: 101854600
• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199735142

✦ Synopsis

Chiral Auxiliary-Bearing Isocyanides as Synthons: Synthesis of Strongly Fluorescent (+)-5-(3,4-Dimethoxyphenyl)-4-((N-((4S)-2oxo-4-( phenylmethyl)-2-oxazolidinyl)) carbonyl)oxazole and Its Enantiomer.

-The title compounds (VIIIa) and (VIIIb) are prepared by treatment of the isocyanates (VI) with the acid chloride (VII). They have high fluorescence quantum yields and, thus, are important as standards in fluorescence-detected circular dichroism for on-column detection in capillary electrophoresis. -(TANG,