ChemInform Abstract: Chemoselective Reaction on a Hydroxy or Aldehyde Group Tethered with a Tri-Substituted Ozonide: A Versatile Methodology for the Preparation of Terminally Differentiated Compounds from Cyclohexene.
✍ Scribed by Y.-S. HON; J.-L. YAN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 45 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
✦ Synopsis
other 5-membered heterocycles (with 3 or more heteroatoms) R 0330
44 -135
Chemoselective Reaction on a Hydroxy or Aldehyde Group Tethered with a Tri-Substituted Ozonide: A Versatile Methodology for the Preparation of Terminally Differentiated Compounds from Cyclohexene.
-It is shown that chemoselective functionalization of aldehyde and ketone groups in the presence of a ozonide moiety is possible under certain Lewis acid, free radical, and organometallic conditions. Subsequent decomposition of the ozonide moiety provides an extremely convenient and versatile route to terminally differentiated compounds like (VI), (VIII), and (IX). -(HON,