ChemInform Abstract: Chemoenzymatic Preparation of the Novel Antifolate Thymidylate Synthase Inhibitor N-(4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic Acid (Ia) and Its Glutamyl Cleavage Product (Ib).

✍ Scribed by Jonathan H. Marriott; Stephen Neidle; Zbigniew Matusiak; Vassilios Bavetsias; Ann L. Jackman; Camille Melin; F. Thomas Boyle

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199937221