ChemInform Abstract: Chemistry of Castanospermine. Part 4. Synthetic Modifications at C-8.
β Scribed by R. H. FURNEAUX; G. J. GAINSFORD; J. M. MASON; P. C. TYLER; O. HARTLEY; B. G. WINCHESTER
- Book ID
- 112029075
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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Remote O, C-Dianion Chemistry of Pyroglutamates: Reaction at C-4 with Electrophiles. -Lithiation of N-substituted pyroglutamic acids (I) generates O,C-di-lithio enolates which react diastereoselectively with alkyl halides (II) to give exclusively the 4-Ξ±-substituted products (IV) after esterificati