ChemInform Abstract: Catalytic Hydrogenation of Phosphate Enol Esters Present in Branched Chain Dienepyranosides in a Route to Thromboxane Analogues from D-Galactose.
✍ Scribed by Oscar Moradei; Cecile M. du Mortier; Alicia Fernandez Cirelli; Joachim Thiem
- Book ID
- 101881607
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Catalytic Hydrogenation of Phosphate Enol Esters Present in Branched Chain Dienepyranosides in a Route to Thromboxane Analogues from D-Galactose.
-Dienopyranosides such as (I) are subjected to catalytic hydrogenation under different conditions. Heterogeneous catalytic hydrogenation results in nearly all cases in the formation of the dihydro derivatives like (II) as major products, which are resistant to further hydrogenation. However, under homogeneous conditions, complete stereoselective hydrogenation is achieved. Applying Brown's catalyst, the pyranoside (VIII) is obtained, a potential precursor of thromboxane analogues. -(MORADEI,