ChemInform Abstract: Catalytic Asymmetric Nitroaldol Reaction of α,α-Difluoro Aldehydes Mediated by Rare Earth-Lithium-BINOL Complexes.

✍ Scribed by K. ISEKI; S. OISHI; H. SASAI; M. SHIBASAKI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199716042

✦ Synopsis

Catalytic Asymmetric Nitroaldol Reaction of α,α-Difluoro Aldehydes Mediated by Rare Earth-Lithium-BINOL Complexes.

-Rare earth-Li-BINOL complexes are useful catalysts for the enantioselective nitroaldol reaction of α,α-difluoro aldehydes (I) with nitromethane to yield the products (III) with good stereoselectivity. The enantiotopic face selection of (Ia) is found to be different from that of the nonfluorinated analogue in usual catalytic asymmetric nitroaldol reactions. -(ISEKI, K.;