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ChemInform Abstract: Cadogan—Sundberg Indole Synthesis

✍ Scribed by Jie Jack Li


Book ID
112044383
Publisher
John Wiley and Sons
Year
2012
Weight
18 KB
Volume
43
Category
Article
ISSN
0931-7597

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Synthesis of 2-nitroindoles via the Sund
✍ Erin T. Pelkey; Gordon W. Gribble 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 178 KB

A three-step sequence has been developed for converting o-nitrobenzaldehydes into 2nitroindoles. The key step involves the thermolysis of 2-(o-azidophenyl)nigoethylene (10) in xylenes which gives 2-nitroindole (4) in 54% yield, akin to the classic Sundberg indole synthesis. This p~ure has also been