ChemInform Abstract: Built-In 5-Aminooxazole as an Internal Activator of the Terminal Carboxylic Acid: An Alternative Access to Macrocyclodepsipeptides

5-Aminooxazole as an Internal Traceless

5-Aminooxazole as an Internal Traceless Activator of C-Terminal Carboxylic Acid: Rapid Access to Diversely Functionalized Cyclodepsipeptides

✍ Carine Bughin; Gang Zhao; Hugues Bienaymé; Jieping Zhu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract A conceptually novel macrolactonization protocol has been developed. It is a domino process involving a sequence of: 1) protonation of 5‐aminooxazole leading to the electrophilic iminium salt; 2) trapping of the iminium species by the neighboring C‐terminal carboxylic acid leading to a