ChemInform Abstract: Bis-8-hydroxyquinoline and Bis-8-hydroxyquinaldine N-Substituted Amines: A Single Methyl Group Structural Difference Between the Two Heterocycles, which Modulates the Antiproliferative Effects.

Bis-8-hydroxyquinoline and bis-8-hydroxy

Bis-8-hydroxyquinoline and bis-8-hydroxyquinaldine N-substituted amines: A single methyl group structural difference between the two heterocycles, which modulates the antiproliferative effects

✍ Sébastien Madonna; Aline Marcowycz; Delphine Lamoral-Theys; Gwendoline Van Goiet 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 114 KB

## Abstract magnified image The synthesis of a series of bis‐8‐hydroxyquinoline‐ and bis‐8‐hydroxyquinaldine‐substituted __N__‐benzyl or thiophenyl amines and their corresponding bis‐8‐hydroxyquinoline is reported. __In vitro__ growth inhibitory effects of both series have been evaluated. It has b