ChemInform Abstract: Biotransformation of Organic Sulfides. Predictive Active Site Models for Sulfoxidation Catalyzed by 2,5-Diketocamphane 1,2-Monooxygenase and 3,6-Diketocamphane 1,6-Monooxygenase, Enantiocomplementary Enzymes from Pseudomonas putida NCIMB 10007.
✍ Scribed by J. BEECHER; A. WILLETTS
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 39 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
1998
sulfoxides, sulfones, sulfenes and derivatives sulfoxides, sulfones, sulfenes and derivatives (benzene compounds) Q 0600
42 -100
Biotransformation of Organic Sulfides.
Predictive Active Site Models for Sulfoxidation Catalyzed by 2,5-Diketocamphane 1,2-Monooxygenase and 3,6-Diketocamphane 1,6-Monooxygenase, Enantiocomplementary Enzymes from Pseudomonas putida NCIMB 10007.
-Results of the title reaction of 23 sulfides of type (I) and (III) are computed into cubic space models, depicting the binding pockets of the active sites of the title enzymes. This empirical approach is the first which provides insight into the active-site topography of FMN plus NADH-dependent Baeyer-Villiger monooxygenases. The cubic space modelling approach has the advantage of being a dynamic mode-of-action model which allows explanation and prediction of stereoselectivities.
-(BEECHER,