✦ LIBER ✦
ChemInform Abstract: Biomimetic Synthesis of (-)-Xestospongin A (IX), (+)-Xestospongin C (VIII), (+)-Araguspongine B (VII) and the Correction of Their Absolute Configurations.
✍ Scribed by J. E. BALDWIN; A. MELMAN; V. LEE; C. R. FIRKIN; R. C. WHITEHEAD
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Biomimetic Synthesis of (-)-Xestospongin A (IX), (+)-Xestospongin C (VIII), (+)-Araguspongine B (VII) and the Correction of Their Absolute Configurations.
-Key steps in the synthesis of title compounds (VII)-(IX) are stereoselective formation of the hydroxy ester (III), dimerization of the pyridine (IV), intramolecular ring closure yielding the bis-oxaquinolizidine (VI), and reduction of (VI).The results unambiguously establish that the natural compounds are the enantiomers in all three cases.
-(BALDWIN,