✦ LIBER ✦
ChemInform Abstract: Biomimetic Reductive Amination of Fluoro Aldehydes and Ketones via (1, 3)-Proton Shift Reaction. Scope and Limitations.
✍ Scribed by T. ONO; V. P. KUKHAR; V. A. SOLOSHONOK
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Biomimetic Reductive Amination of Fluoro Aldehydes and Ketones via (1, 3)-Proton Shift Reaction. Scope and Limitations.
-Azomethine-azomethine isomerization of the fluorinated Schiff's bases ( III) and (IX) (14 examples) affords the corresponding N-benzylidene derivatives in good yields, which can be transformed into fluorine-containing amines of potential biological interest. In the case of chlorine-and bromine-containing derivatives such as (IIIe), (IIIf) and (XII), additional dehydrohalogenation takes place. -