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ChemInform Abstract: Bioinorganic Chemistry of Copper and Zinc Ions Coordinated to Amyloid-β Peptide

✍ Scribed by Peter Faller; Christelle Hureau

Publisher
John Wiley and Sons
Year
2009
Weight
16 KB
Volume
40
Category
Article
ISSN
0931-7597

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## Abstract __The metal ions copper, zinc and iron have been shown to be involved in Alzheimer's disease (AD). Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid‐β (Aβ), and 2) production of reactive oxygen species (ROS) induced