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ChemInform Abstract: Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide.

✍ Scribed by T. SUGAI; K. HAMADA; T. AKEBOSHI; H. IKEDA; H. OHTA

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199751152

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✦ Synopsis

Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide.

-Enantioselective reduction of 5-oxohexanoic acid (I) using whole cell culture of Yamadazyma farinosa IFO 10896 and subsequent Amano PS lipase mediated kinetic resolution of the ester (III) yields the desired product (V) in very high e.e. Hydrolysis and following lactonization provides the valuable chiral building block (VI). -(SUGAI,

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