ChemInform Abstract: Bioactive Hydroxyethylene Dipeptide Isosteres with Hydrophobic (P3-P1)- Moieties. A Novel Strategy Towards Small Non-Peptide Renin Inhibitors.

Bioactive hydroxyethylene dipeptide isos

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

✍ Vittorio Rasetti; N.Claude Cohen; Heinrich Rüeger; Richard Göschke; Jürgen Maiba 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 426 KB

The design and synthesis of new truncated 8-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-p