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ChemInform Abstract: Asymmetric Synthesis of the Cytotoxic Marine Natural Product (+)-Awajanomycin (I) and Its C-11 Epimer.

✍ Scribed by Rui Fu; Jian-Liang Ye; Xi-Jie Dai; Yuan-Ping Ruan; Pei-Qiang Huang


Publisher
John Wiley and Sons
Year
2010
Weight
18 KB
Volume
41
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
✍ S. P. EAST; F. SHAO; L. WILLIAMS; M. M. JOULLIE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 34 KB πŸ‘ 2 views

Total Synthesis of the Cyclopeptide Alkaloid Sanjoinine G1 and Its C-11 Epimer. -An efficient new synthesis (18 steps, 6.6% overall yield) of sanjoinine G1 (VIII) is reported. The key steps in this synthesis are the formation of the alkyl-aryl ether linkage via an S N Ar reaction of amino alcohol (