ChemInform Abstract: Asymmetric Synthesis of (S,S,S)-2-Aza-bicyclo[3.3.0]-octane-3-carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril.
β Scribed by G. C. M. Kondaiah; M. Vivekanandareddy; L. Amarnath Reddy; Smita V. Anurkar; V. M. Gurav; M. Ravikumar; Apurba Bhattacharya; Rakeshwar Bandichhor
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 34 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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The synthesis of 3-prolinomethionine can be easily achieved in a diastereoselective and enantioselective way via zinc-enolate cyclisation. After transmetallation by CuCN.2LiCI, the zinc--copper derivative was reacted with S-methyl methanesulfonothioate leading in a "one-pot" procedure, to N-(0t-meth