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ChemInform Abstract: Asymmetric Synthesis of Both Enantiomers of Pyrrolidinoisoquinoline Derivatives from L-Malic Acid and L-Tartaric Acid.

โœ Scribed by Y. S. LEE; D. W. KANG; S. J. LEE; H. PARK


Book ID
112029397
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of Dioxolanylclavam from Tartaric Acid. -(2 + 2) Cycloaddition of the 3-O-vinyl ether (I) derived from tartaric acid to chlorosulfonyl isocyanate (II) gives the 4-alkoxyazetidinone ( III) with good diastereoselectivity. Cyclization provides the clavam ( IV) missing the C-3 carboxylic funct