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ChemInform Abstract: Asymmetric Synthesis of Boc-β2-homophenylglycine.

✍ Scribed by R. PONSINET; G. CHASSAING; S. LAVIELLE


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis


Asymmetric Synthesis of Boc-β 2 -homophenylglycine.

-Key step in the synthesis of the title compound, which is presented with a view to the current interest in non-proteinogenic amino acids, is the diastereoselective acylation of phenylacetonitrile with sultam carbonyl chloride (II), prepared from Oppolzer's sultam and triphosgene.


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