✦ LIBER ✦
ChemInform Abstract: Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif.
✍ Scribed by Kun Jiang; Zhi-Jun Jia; Xiang Yin; Li Wu; Ying-Chun Chen
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 66 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
A three‐component, domino Michael—Michael—Michael—aldol process of the indole‐derived substrates of the type (I) with two identical or different molecules of α,β‐unsaturated aldehydes under quadruple iminium/enamine/iminium/enamine catalysis affords a variety of the enantiomerically pure hydroindane derivatives, bearing six contiguous stereocenters and a spirooxindole motif with complete diastereoselectivities [cf.