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ChemInform Abstract: Asymmetric Dihydroxylation Route to a Dipeptide Isostere of a Protease Inhibitor: Enantioselective Synthesis of the Core Unit of Ritonavir.

✍ Scribed by Arun K. Ghosh; Dongwoo Shin; Packiarajan Mathivanan

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199938182

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✦ Synopsis

Asymmetric Dihydroxylation Route to a Dipeptide Isostere of a Protease Inhibitor: Enantioselective Synthesis of the Core Unit of Ritonavir.

-An enantioselective synthesis of the core unit of ritonavir is given which uses Sharpless' catalytic asymmetric dihydroxylation reaction as the key step. Ritonavir is a potent, selective and clinically effective protease inhibitor. The present route provides access to a diverse array of protease inhibitors containing designed functionalities. -(GHOSH, ARUN K.; SHIN,

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