ChemInform Abstract: Asymmetric Bridging Annulation Reaction Involving the Intramolecular Conjugate Addition of Chiral Imines to Enoates: Access to a Polycyclic System Related to the Taxane Core.

Asymmetric bridging annulation reaction

Asymmetric bridging annulation reaction involving the intramolecular conjugate addition of chiral imines to enoates: Access to a polycyclic system related to the taxane core

✍ Christian Cavé; Sophie Boggero; Ramon Casas; Françoise Dumas; Jacqueline Mahutea 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 232 KB

R )-l-phenylethylamine-induced cyclization of ketoenoate 2 4 led to a 2:1 mixture of "all-cis" polycyclic adducts 2 5 and 2 6, structurally related to the taxane series. Ten years ago, we reported that chiral imines 3, derived from racemic 2-alkylcyclanones 1 and optically active 1-phenylethylamine