✍ Scribed by O. NICAISE; S. DENMARK
No coin nor oath required. For personal study only.
Asymmetric Addition of Organometallic Reagents to Chiral α-Alkoxy Hydrazones.
-The diastereoselective addition of three different types of nucleophilic reagents to three different α-alkoxy hydrazones is studied. With exception of the reation of the silylated hydrazone (Ib) with the heterogeneous 1:1 reagent, high yields and stereoselectivities are observed. Hydrogenolytic removal of the chiral auxiliary with Raney nickel is found to proceed with some epimerization. -(NICAISE, O.;
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
We studied the nucleophilic addition of organocerium reagents to ␣-alkoxy hydrazones. The results depend upon the organocerium reagents, the nature of protection for the hydroxy group, and the solvents used. Contrary to Grignard reagents, organocerium reagents derived from Grignard reagents effectiv