ChemInform Abstract: Antimalarially Potent, Easily Prepared, Fluorinated Endoperoxides.

✍ Scribed by G. H. POSNER; X. TAO; J. N. CUMMING; D. KLINEDINST; T. A. SHAPIRO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 26 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199702132

✦ Synopsis

The bicyclic endoperoxides (I) and (II) are easily prepared from commercially available chemicals. In vitro testing shows, that compounds (Ic) and (IIc) are potent antimalarials having 15% of the activity of the clinically used artemisinin. -(POSNER, G.