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ChemInform Abstract: Antiinflammatory 2-Benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: Novel Inhibitors of COX-2.

✍ Scribed by E. S. LAZER; R. SORCEK; C. L. CYWIN; D. THOME; G. J. POSSANZA; A. G. GRAHAM; L. CHURCHILL

Book ID: 101869842
Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199838165

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✦ Synopsis

Antiinflammatory

2-Benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: Novel Inhibitors of COX-2.

-The title compounds are investigated for their antiinflammatory activity. The most potent derivative is (IIId) with selective COX-2-inhibition due to the 6-chloro substitution. -(LAZER, E.

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