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ChemInform Abstract: Antibiotic Resistance versus Small Molecules, the Chemical Evolution

โœ Scribed by Ving J. Lee; Scott J. Hecker


Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
31
Category
Article
ISSN
0931-7597

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Antibiotic resistance versus small molec
โœ Ving J. Lee; Scott J. Hecker ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 402 KB ๐Ÿ‘ 1 views

Two discovery approaches directed to addressing the problem of increasing bacterial resistance are described. The first is a program to build activity against methicillin-resistant Staphylococcus aureus (MRSA) into the cephalosporin class of antibacterials, by enhancing affinity for PBP2a, the penic