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ChemInform Abstract: Anti-Aids Agents. Part 33. Synthesis and anti-HIV Activity of Mono-Methyl Substituted 3′,4′-Di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) Analogues.

✍ Scribed by L. XIE; Y. TAKEUCHI; L. M. COSENTINO; K.-H. LEE

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199901141

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✦ Synopsis

Anti-Aids Agents. Part 33. Synthesis and anti-HIV Activity of Mono-Methyl Substituted 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) Analogues.

-The title compounds (VII) are synthesized using a Claisen rearrangement and a Sharpless dihydroxylation reaction as key steps. The methyl derivatives (VII) exhibit a significant higher activity compared with unsubstituted DCK (no yields given).

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