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ChemInform Abstract: An Expeditious Synthesis of Z-3-Alkylidene Isoindolinones via Combined Palladium Catalyzed and Friedel-Crafts Reactions.

✍ Scribed by N. G. KUNDU; M. W. KHAN


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


1997

indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140

52 -140

An Expeditious Synthesis of Z-3-Alkylidene Isoindolinones via Combined Palladium Catalyzed and Friedel-Crafts Reactions.

-The regio-and stereoselective synthesis of isoindolines (V) utilizes the Pd-catalyzed reaction between o-iodobenzamides (I) and trimethylsilyl acetylene to give the silylated ethynyl benzamides (III) . Their Friedel-Crafts acylation and cyclization yields the desired targets (V). -(KUNDU, N. G.; KHAN, M. W.;


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