ChemInform Abstract: An Efficient Synthesis of Tetraethyl Fluoromethylenediphosphonate and Derivatives from Diethyl Dibromofluoromethylphosphonate.

✍ Scribed by B. IORGA; F. EYMERY; P. SAVIGNAC

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 28 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199835211

✦ Synopsis

An Efficient Synthesis of Tetraethyl Fluoromethylenediphosphonate and Derivatives from Diethyl Dibromofluoromethylphosphonate. -Treatment of phosphonate (I) with an equivalent amount of BuLi and subsequent quenching with a variety of electrophiles provides an efficient synthesis of pharmaceutically interesting fluorinated diphosphonates.

-(IORGA,