ChemInform Abstract: An Efficient Route to β-D-Isoxazolidinyl Nucleosides via Diastereoselective Michael Addition of Hydroxylamine to Unsaturated Esters.

✍ Scribed by Y. XIANG; H.-J. GI; D. NIU; R. F. SCHINAZI; K. ZHAO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 41 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199811249

✦ Synopsis

An Efficient Route to β-D-Isoxazolidinyl Nucleosides via Diastereoselective Michael Addition of Hydroxylamine to Unsaturated Esters.

-The key steps in the synthesis of title compounds like (VIII), (XI), and (XV), which are biologically interesting molecules, are diastereoselective addition of the hydroxylamine (II) to the ester (I) and cis-selective coupling of the acetate (V) with nucleoside bases. -(XIANG, Y.;