## Abstract An efficient Michael addition of indoles to electronβdeficient olefins under solventβ and catalystβfree condition afforded biologically important 3βsubstituted indole derivatives in good to excellent yields was reported. The acidic Nο£ΏH proton of indole plays a key role in Michael additi
ChemInform Abstract: An Efficient and Clean Michael Addition of Indoles to Electron-Deficient Olefins under Solvent- and Catalyst-Free Condition.
β Scribed by Xiong-Li Liu; Dong Xue; Zun-Ting Zhang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 32 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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The Ultra High Pressure Conjugate Addition of Indoles to Electron-Deficient Olefins. -Indole and methylindole are added to Ξ±,Ξ²-unsaturated ketones in the presence of catalytic amounts of Yb(OTf) 3 to afford 3-alkylated indoles. The more reactive and less sterically hindered electrophiles give good t
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