ChemInform Abstract: An Easy Strategy for the Synthesis of 5-Phosphorylated Pyrimidin-2,4-diones from β-Phosphine Oxide and Phosphonate Enamines.

✍ Scribed by Francisco Palacios; Domitila Aparicio; Ana M. Ochoa de Retana; Jesus M. de los Santos; Jesus Garcia; Julen Oyarzabal

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199928205

✦ Synopsis

An Easy Strategy for the Synthesis of 5-Phosphorylated Pyrimidin-2,4-diones from β-Phosphine Oxide and Phosphonate Enamines. -An efficient synthesis of the title 5-phosphorylated pyrimidinediones (III), (V) and (VII) is presented involving the base-catalyzed cyclization of functionalized enamides/imine amides (I), (IV) and (VI), resp., with ethyl chloroformate (II). In the same way, thioamides afford the corresponding 5-phosphorylated 2-oxopyrimidine-4-thiones (IIId) and (Vd).

-(PALACIOS, FRANCISCO;