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ChemInform Abstract: An Acid-Catalyzed O,N-Acyl Migration and Application to the Synthesis of N-(4-Isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo [1,4]oxazine-6-carbonyl)guanidine Methanesulfonate (KB-R9032), a Novel Na/H Exchange Inhibitor.

✍ Scribed by Takeshi Yamamoto; Manabu Hori; Ikuo Watanabe; Hisayoshi Tsutsui; Shoji Ikeda; Hiroshi Ohtaka

Publisher
John Wiley and Sons
Year
2010
Weight
40 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Design, Synthesis and Quantitative Structure-Activity Relationship Study of 4]oxazine-7carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors. -A series of racemic as well as optically active (benzoxazine-7carbonyl)guanidine derivatives (VIII) are designed and synthesized starting from 4