ChemInform Abstract: Aminoenylesters. Part 1. A New Synthesis of 1,2,3,4- Tetrahydropyrimidines by Heterocyclic Anellation Reactions of Aminoenylesters with Primary Amines and Acetaldehyde.

✍ Scribed by T. KOIKE; M. TANABE; N. TAKEUCHI; S. TOBINAGA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 28 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199750156

✦ Synopsis

Aminoenylesters. Part 1. A New Synthesis of 1,2,3,4-Tetrahydropyrimidines by Heterocyclic Anellation Reactions of Aminoenylesters with Primary Amines and Acetaldehyde. -A novel heterocyclization reaction is presented. Reaction of the methyl propiolate (I) with primary amines (II) gives the enamines (III) which on coupling with acetaldehyde and primary amines produce tetrahydropyrimidines (V) in moderate to high yields.

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