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ChemInform Abstract: Amide Activation by Tf2O: Reduction of Amides to Amines by NaBH4 under Mild Conditions.

✍ Scribed by Shao-Hua Xiang; Jian Xu; Hong-Qiu Yuang; Pei-Qiang Huang

Publisher: John Wiley and Sons
Year: 2010
Weight: 25 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201048054

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✦ Synopsis

Abstract

The reaction of triflic anhydride with amides generates a highly electrophilic iminium triflate intermediate which is reduced by NaBH~4~ to give the target amines.

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