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ChemInform Abstract: Ambident Isothiocyanatomethanide Anion for Regioselective Synthesis of Thiazoles.

✍ Scribed by L. BRANDSMA; N. A. NEDOLYA; B. A. TROFIMOV


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis


Ambident Isothiocyanatomethanide Anion for Regioselective Synthesis of Thiazoles.

-Reaction of methyl isothiocyanate (I) with LDA affords an ambident isothiocyanatomethanide anion which smoothly cyclizes with a second molecule of compound (I) to give a 5-methylamino-1,3-thiazole-2-thiolate, isolated as its 5-dimethylamino-2-methylthio analogue (III). -


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