ChemInform Abstract: Alternative Synthesis of Duocarmycin SA Using a Tricyclic Heteroaromatic Intermediate Prepared by Palladium-Catalyzed Coupling Reactions.

✍ Scribed by H. MURATAKE; M. TONEGAWA; M. NATSUME

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199711239

✦ Synopsis

Alternative Synthesis of Duocarmycin SA Using a Tricyclic Heteroaromatic Intermediate Prepared by Palladium-Catalyzed Coupling Reactions.

-The key intermediate of this new approach of the title compound is the heterocycle (IX), which in further steps leads to the known synthetic precursor (XII) of duocarmycin SA. The possibility of optical resolution after the removal of the phenolic COOMe group with (R)-O-methylmandelate is also given. -(MURATAKE, H.; TONEGAWA, M.; NATSUME, M.; Chem.