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ChemInform Abstract: Alkaline Biocatalysis for the Direct Synthesis of N-Acetyl-D-neuraminic Acid (Neu5Ac) from N-Acetyl-D-glucosamine (GlcNAc)

โœ Scribed by Simone Blayer; John M. Woodley; Michael J. Dawson; Malcolm D. Lilly


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
31
Category
Article
ISSN
0931-7597

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Alkaline biocatalysis for the direct syn
โœ Simone Blayer; John M. Woodley; Michael J. Dawson; Malcolm D. Lilly ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 108 KB ๐Ÿ‘ 2 views

Integration between the alkaline epimerization of N-acetyl-D-glucosamine (GlcNAc) to N-Acetyl-Dmannosamine (ManNAc) and the N-acetyl-D-neuraminic acid (Neu5Ac) aldolase-catalyzed biotransformation has been assessed experimentally. GlcNAc epimerization took place above pH 9.0, and the initial rate of