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ChemInform Abstract: Adociasulfates 1, 7, and 8: New Bioactive Hexaprenoid Hydroquinones from the Marine Sponge Adocia sp.

✍ Scribed by John A. Kalaitzis; Priscila de Almeida Leone; Lisa Harris; Mark S. Butler; Anna Ngo; John N. A. Hooper; Ronald J. Quinn

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199947204

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✦ Synopsis

quinones from the Marine Sponge Adocia sp.

-The structures of adociasulfates 1 (Ia), 7 (Ib), and 8 (II) are elucidated by 2D-NMR spectroscopy. Whereas bisulfate (Ia) inhibits proton pump activity in hen bone-derived membrane vesicles, monosulfate (Ib) possesses 10-fold decreased potency and adociasulfate 8 is even less active.

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