ChemInform Abstract: Addition Reactions of Cyclic s-trans-Enaminones with Grignard Reagents.

✍ Scribed by T. T. SHAWE; D. B. HANSEN; K. A. PEET; A. S. PROKOPOWICZ; P. M. ROBINSON; A. CANNON; K. E. DOUGHERTY; A. A. ROSS; L. M. LANDINO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199720081

✦ Synopsis

Addition Reactions of Cyclic s-trans-Enaminones with Grignard Reagents.

-Depending on the solvent polarity and coordinating ability, the title reaction leads to 3-alkylcycloalkenones and bis-adducts. Addition of phenylmagnesium bromide gives 3-phenyl substituted cycloalkenones without regard to the solvent. Alkylmagnesium halides in CH2Cl2 give mixtures of the products. Only in THF the 3-alkylcycloalkenones are solely formed. -(SHAWE, T.