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ChemInform Abstract: A Versatile Synthesis of Tricyclic Analogues of Quinolone Antibacterial Agents: Use of a Novel Reformatsky Reaction.

✍ Scribed by J. P. MICHAEL; C. B. DE KONING; T. V. STANBURY

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

A Versatile Synthesis of Tricyclic Analogues of Quinolone Antibacterial Agents: Use of a Novel Reformatsky Reaction.

-Nine pyrrolo(1,2-a)quinolone-4-carboxylic acids (IV) are synthesized involving Reformatsky reaction of (I) with diethyl bromomalonate and subsequent cyclization as the key steps. Compound (IVc) is further converted into the known biologically active pefloxacin analogue (V). -(MICHAEL,

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