ChemInform Abstract: A Stereoselective Synthesis of 1α-(3′-Carboxypropyl)-4-androsten-17β-ol-3-one: Preparation of Immunoreagents for Quantification of Testosterone by Fluorescence Polarization Immunoassay.

✍ Scribed by M. ADAMCZYK; Y.-Y. CHEN; D. D. JOHNSON; R. E. REDDY

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199802205

✦ Synopsis

A Stereoselective Synthesis of 1α-(3'-Carboxypropyl)-4-androsten-17β-ol-3-one: Preparation of Immunoreagents for Quantification of Testosterone by Fluorescence Polarization Immunoassay. -Silyl-protected boldenone (I) is transformed to the title carboxylic acid (IV) via stereoselective introduction of the C-1 side chain. After liberation of the C-17 hydroxy group, modification of the terminal acid residue at C-1 affords two immunogens and three fluorescent tracers for testosterone immunoassays.