ChemInform Abstract: A Simple Synthetic Method for Fluorine-Containing 4H-Pyrano[3,2-d]isoxazoles and 4-Cyanoethylisoxazoles from 5-Trifluoroacetyl-2-methoxy-3,4-dihydro-2H-pyran with Hydroxylamine Hydrochloride.

✍ Scribed by Etsuji Okada; Hiroshi Okumura; Yukihiro Nishida; Takeshi Kitahora

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199923152

✦ Synopsis

1999 isoxazole derivatives isoxazole derivatives R 0240 23 -152 A Simple Synthetic Method for Fluorine-Containing 4H-Pyrano[3,2d]isoxazoles and 4-Cyanoethylisoxazoles from 5-Trifluoroacetyl-2methoxy-3,4-dihydro-2H-pyran with Hydroxylamine Hydrochloride. -As part of a research program on the synthesis of CF 3 -containing heterocycles, pyran (I) is treated with hydroxylamine hydrochloride and alcohols (II) to give 4H-pyrano[3,2-d]isoxazoles (III). Ethyl derivative (IIIa) is easily converted into dihydroisoxazole (IV) and isoxazole (V). -(OKADA, ETSUJI;