ChemInform Abstract: A Simple and Efficient Synthetic Route to Chiral Isopavines. Synthesis of (-)-O-Methylthalisopavine and (-)-Amurensinine.

✍ Scribed by L. CARRILLO; D. BADIA; E. DOMINGUEZ; J. L. VICARIO; I. TELLITU

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199809209

✦ Synopsis

A Simple and Efficient Synthetic Route to Chiral Isopavines. Synthesis of (-)-O-Methylthalisopavine and (-)-Amurensinine.

-The key steps in the synthesis of the title compounds (VIII) are stereoselective addition of the Grignard reagent (II) to the imines (I) and a novel one-pot double-intramolecular cyclization of the acetals (V). -(CARRILLO, L.;